Pharmacophore-Based Techniques For the Construction of Biochemical Reaction Networks
نویسندگان
چکیده
In silico models for biochemical systems are usually built by extracting in vitro kinetic expressions for each enzyme-catalysed reaction from databases. This method, however, assumes that the enzyme kinetics measured in isolation will be the same as those in complex systems (in vivo). Also, these models require that all the kinetic expressions and all the reactions are known. If this knowledge is missing and there are reactions occurring which are not considered or which have no kinetic data then the models built will be inaccurate.
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تاریخ انتشار 2007